News
News/Topics List
- Prof. Mizushima has been recognized as Web of Science, Highly Cited Researchers in 2024 (11th consecutive year).
- Dr. Hayashi won an Excellent Poster Award at the 16th Autophagy Research Meeting for Young Scientists
- Jing Zhang-san won the Best Student Poster Presentation Award at The 76th Annual Meeting of the Japanese Society for Cell Biology
- Cantona-san won the Best Poster Award at WINGS LST general meeting
- Yamaguchi-san received the Best Poster Abstract Award at the 2023 ‘Medical Scientist Training Program’ Retreat
- Kanda-san won the MBSJ2023 Best Science Pitch Award at the 46th Annual Meeting of the Molecular Biology Society of Japan
- Dr. Eguchi won the Best Presentation Award at the 15th Autophagy Research Meeting for Young Scientists
- Prof. Mizushima have been recognized as Web of Science, Highly Cited Researchers in 2023 (10th straight year).
- Kanda-san, Okawa-san and Nagashima-san won Young Scientists Presentation Award of Excellence at the 96rd Annual Meeting of Japanese Biochemical Society
- Dr. Eguchi won the EMBO reports poster prize at the EMBO COB Workshop on Membrane shaping and remodeling by proteins in Kunming
- Prof. Mizushima awarded inaugural Beth Levine, M.D. Prize in Autophagy Research
- Okawa-san won an Excellent Poster Award at the 22th BioUT (Life Science Symposium at the University of Tokyo)
- Nagashima-san and Suzuki-san received an Excellent Poster Abstract Award and the Best Poster Abstract Award respectively at the 2022 ‘Medical Scientist Training Program’ Retreat
- Shimasawa-san received the 2020 SATOSHI ARIMA Memorial Fellowship
- Prof. Mizushima have been recognized as Web of Science, Highly Cited Researchers in 2022 (9th straight year).
- Shimasawa-san received an Excellent Poster Abstract Award at the 2021 ‘Medical Scientist Training Program’ Retreat
- Dr. Chino received Inoue Research Award for Young Scientists.
- Prof. Mizushima was selected as a 2021 Clarivate Analytics Highly Cited Researcher (8th straight year)
- The ERATO Symposium was held on Thursday, November 11, 2021
- The ERATO International Symposium was held on Thursday, June 17, 2021
- Prof. Mizushima was awarded the Medal of Honor with Purple Ribbon
- Shimasawa-san and Suzuki-san received an Excellent Poster Abstract Award and the Best Poster Abstract Award respectively at the 2020 ‘Medical Scientist Training Program’ Retreat
- Oshima-san received the Dean’s Award from ‘Medical Scientist Training Program’ Thesis Review Committee, and Mimura-san received the 2020 SATOSHI ARIMA Memorial Fellowship
- Prof. Mizushima received “Minister of MEXT Award” at the 4th Award Ceremony for the Japan Medical Research and Development Grand Prize
- Prof. Mizushima was selected as a 2020 Clarivate Analytics Highly Cited Researcher (7th straight year)
- Prof. Mizushima received the Medical Award of the Japan Medical Association
- Yamamoto-san won Young Scientists Presentation Award of Excellence at the 93rd Annual Meeting of Japanese Biochemical Society
- Prof. Mizushima won the 61st Fujihara Award
- Prof. Mizushima has been elected as an EMBO Associate Member
- Dr. Morishita received a Young Scientist Presentation Award of Excellence at the 72nd Annual Meeting of the Japan Society for Cell Biology
- Mimura-san won an Excellent Poster Abstract Award at the 2019 ‘Medical Scientist Training Program’ Retreat
- Prof. Mizushima was selected as a 2019 Clarivate Analytics Highly Cited Researcher (6th straight year)
- Both Dr. Morishita and Oshima-san received a ‘Best Poster Award’ at the 9th International Symposium on Autophagy.
- Dr.Chino won Young Scientists Presentation Award of Excellence at at the 92nd Annual Meeting of the Japanese Biochemical Society
- Dr. Morishita received an Excellent Presentation Award from the 58th Annual Meeting of the Japanese Society for Cataract Research / the 45th Annual Meeting of the Japanese Society for Crystalline Lens Research
- A Review Article by Dr. Morishita and Prof. Mizushima was published in Annu Rev Cell Dev Biol
- Dr. Honda won an Excellent Poster Award at the EMBO Workshop
- Dr. Sakamoto won the 28th Incentive Award in Japanese Society of Parsitology
- Ohshima-san won an Excellent Poster Abstract Award at the 2018 ‘Medical Scientist Training Program’ Retreat
- Prof. Mizushima was selected as a 2018 Clarivate Analytics Highly Cited Researcher (Fifth straight year) !
- Tamura-san and Morita-san won Young Scientists Presentation Award of Excellence at the 91st Annual Meeting of Japanese Biochemical Society
- Chino-san won the Nature Structural & Molecular Biology Poster Prize at the International Symposium on Proteins: From the Cradle to the Grave
- Kanda-san won an Excellent Poster Award at the 18th BioUT (Life Science Symposium at the University of Tokyo)
- Prof. Mizushima’s Review was published in Nature Cell Biology
- Mizushima ERATO Project (JST) has been launched
Recent Publications (Original) List
- Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates (Yang et al. EMBO J)
- Organelle landscape analysis using a multi-parametric particle-based method (Kurikawa, Honda et al. PLoS Biol.)
- Optogenetic tools for inducing organelle membrane rupture (Nagashima et al. bioRxiv)
- Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation (Shinoda et al. eLife)
- Experimental determination and mathematical modeling of standard shapes of forming autophagosomes (Sakai et al., Nat. Commun.)
- TAX1BP1 recruits ATG9 vesicles through SCAMP3 binding (Hama et al. bioRxiv)
- Comprehensive analysis of autophagic functions of WIPI family proteins and their implications for the pathogenesis of β-propeller associated neurodegeneration (Shimizu et al., Hum Mol Genet.)
- Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3 (Nishimura et al., Sci Adv.)
- The pH-sensing Rim101 pathway regulates cell size in budding yeast
- Quantitative 3D correlative light and electron microscopy of organelle association during autophagy (Takahashi et al., Cell Struct Funct.)
- Ubiquitination of phosphatidylethanolamine in organellar membranes (Sakamaki et al., Mol. Cell)
- NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy（大島 et al., J. Cell Biol.）
- A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag (Yim et al., eLife)
- Evolutionary diversification of the autophagy-related ubiquitin-like conjugation systems (Zhang et al., Autophagy)
- Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins (Chino et al., EMBO Rep.)
- Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair (Yim et al., FEBS Lett)
- An exploratory text analysis of the autophagy research field (Yim, et al., Autophagy)
- NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA (Yamamoto, et al., Nat. Commun.)
- Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy (Mimura, et al., J Biol Chem)
- Organelle degradation in the lens by PLAAT phospholipases (Morishita, et al., Nature)
- Evolution and insights into the structure and function of the DedA superfamily containing TMEM41B and VMP1 (Okawa, Hama, Zhang et al., J Cell Sci)
- Autophagy is required for maturation of surfactant-containing lamellar bodies in the lung and swim bladder (Morishita, et al., Cell Rep.)
- Modeling Membrane Morphological Change during Autophagosome Formation (Sakai, et al., iScience)
- A critical role of VMP1 in lipoprotein secretion (Morishita, et al., eLife)
- Intrinsically disordered protein TEX264 mediates ER-phagy (Chino et al., Mol Cell)
- Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system (Yamamoto et al., Nat Struct Mol Biol)
- Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation (Morita et al., J Cell Biol)
- Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17 (Matsui et al., J Cell Biol)
- Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets (Tamura et al., FEBS Lett)
- Accumulation of undegraded autophagosomes by expression of dominant-negative syntaxin 17 mutants (Uematsu et al., Autophagy)
- Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains (Nishimura et al., EMBO J)
- The ATG conjugation systems are important for degradation of the inner autophagosomal membrane (Tsuboyama, Honda et al., Science)
- An autophagic flux probe that releases an internal control (Kaizuka, Morishita et al., Mol Cell)
- Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons (Yoshii, Kuma et al.)
- Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells (Kishi et al.)
- The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17 (Jiang et al.)
- Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids (Sahani MH et al.)
- Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids (Honda et al.)
- Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle (Naito et al.)
- Deletion of Atg5 and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation (Morishita et al.)
- FIP200 regulates targeting of Atg16L1 to the isolation membrane (Nishimura)
- De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood (Nishimura)
- Proteasome-dependent activation of mTORC1 is essential for autophagy suppression and muscle remodeling following denervation (Quy)
- Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum (Kitamura)
- Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets (Velikkakath, Nishimura)
- Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy (Itakura)
Recent Publications (Review) List
- Ubiquitination of non-protein substrates (Sakamaki and Mizushima, Trends Cell Biol.)
- Autophagy genes in biology and disease (Yamamoto, Zhang et al., Nat Rev Genet.)
- Transient visit of STX17 (syntaxin 17) to autophagosomes (Koyama-Honda and Mizushima, Autophagy)
- Regulation of ER-derived membrane dynamics by the DedA domain-containing proteins VMP1 and TMEM41B (Hama, Morishita et al., EMBO Rep.)
- Breakthroughs and bottlenecks in autophagy research (Mizushima, et al., Trends Mol Med)
- The evolution of autophagy proteins – diversification in eukaryotes and potential ancestors in prokaryotes (Zhang, et al., J Cell Sci)
- Autophagy in human diseases (*Mizushima, N., Levine, B. , N. Engl. J. Med, 2020)
- Beth Levine 1960-2020 (Simon et al. Nat Cell Biol. 2020)
- Autophagy assays for biological discovery and therapeutic development (Mizushima et al. Trends Biochem Sci. 2020)
- ER-phagy: Quality control and turnover of endoplasmic reticulum (Chino et al., Trends Cell Biol)
- Lysosome biology in autophagy (Yim et al., Cell Discov)
- The ATG conjugation systems in autophagy (Mizushima, Curr Opin Cell Biol)
- Diverse cellular roles of autophagy (Morishita et al., Annu Rev Cell Dev Biol)
- The ubiquitin E2 enzyme UBE2QL1 mediates lysophagy (Mizushima, EMBO Rep)
- TMEM41B functions with VMP1 in autophagosome formation (Morita et al., Autophagy)
- YKT6 as a second SNARE protein of mammalian autophagosomes (Mizushima et al., Autophagy)
- A brief history of autophagy from cell biology to physiology and disease (Mizushima, Nat Cell Biol)
- Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations (Deretic et al., Autophagy)
- A dual binding receptor for ER-phagy (Mizushima, Dev Cell)
