• Comprehensive analysis of autophagic functions of WIPI family proteins and their implications for the pathogenesis of β-propeller associated neurodegeneration (Shimizu et al., Hum Mol Genet.)

    Read More

  • Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3 (Nishimura et al., Sci Adv.)

    Read More

  • Prof. Mizushima have been recognized as Web of Science, Highly Cited Researchers in 2022 (9th straight year).

    Read More

  • The pH-sensing Rim101 pathway regulates cell size in budding yeast

    Read More

  • NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy(大島 et al., J. Cell Biol.)

    Read More

  • Ubiquitination of phosphatidylethanolamine in organellar membranes (Sakamaki et al., Mol. Cell)

    Read More

  • A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag (Yim et al., eLife)

    Read More

  • Evolutionary diversification of the autophagy-related ubiquitin-like conjugation systems (Zhang et al., Autophagy)

    Read More

    News/Topics

    and More

    2023/06/23
    Prof. Mizushima awarded inaugural Beth Levine, M.D. Prize in Autophagy Research
    2023/06/19
    Okawa-san won an Excellent Poster Award at the 22th BioUT (Life Science Symposium at the University of Tokyo)
    2023/02/15
    Nagashima-san and Suzuki-san received an Excellent Poster Abstract Award and the Best Poster Abstract Award respectively at the 2022 ‘Medical Scientist Training Program’ Retreat
    2022/12/16
    Shimasawa-san received the 2020 SATOSHI ARIMA Memorial Fellowship
    2022/11/16
    Prof. Mizushima have been recognized as Web of Science, Highly Cited Researchers in 2022 (9th straight year).
    2022/02/14
    Shimasawa-san received an Excellent Poster Abstract Award at the 2021 ‘Medical Scientist Training Program’ Retreat
    2022/02/12
    Dr. Chino received Inoue Research Award for Young Scientists.
    2021/11/17
    Prof. Mizushima was selected as a 2021 Clarivate Analytics Highly Cited Researcher (8th straight year)
    2021/09/10
    The ERATO Symposium was held on Thursday, November 11, 2021
    2021/06/17
    The ERATO International Symposium was held on Thursday, June 17, 2021
    2021/04/30
    Prof. Mizushima was awarded the Medal of Honor with Purple Ribbon
    2021/02/13
    Shimasawa-san and Suzuki-san received an Excellent Poster Abstract Award and the Best Poster Abstract Award respectively at the 2020 ‘Medical Scientist Training Program’ Retreat
    2020/12/25
    Oshima-san received the Dean’s Award from ‘Medical Scientist Training Program’ Thesis Review Committee, and Mimura-san received the 2020 SATOSHI ARIMA Memorial Fellowship
    2020/12/24
    Prof. Mizushima received “Minister of MEXT Award” at the 4th Award Ceremony for the Japan Medical Research and Development Grand Prize
    2020/11/19
    Prof. Mizushima was selected as a 2020 Clarivate Analytics Highly Cited Researcher (7th straight year)

    Recent Publications (Original)

    and More

    2023/07/06
    Comprehensive analysis of autophagic functions of WIPI family proteins and their implications for the pathogenesis of β-propeller associated neurodegeneration (Shimizu et al., Hum Mol Genet.)
    2023/06/28
    Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3 (Nishimura et al., Sci Adv.)
    2023/03/03
    The pH-sensing Rim101 pathway regulates cell size in budding yeast
    2022/12/22
    Quantitative 3D correlative light and electron microscopy of organelle association during autophagy (Takahashi et al., Cell Struct Funct.)
    2022/09/06
    Ubiquitination of phosphatidylethanolamine in organellar membranes (Sakamaki et al., Mol. Cell)
    2022/08/31
    NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy(大島 et al., J. Cell Biol.)
    2022/08/16
    A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag (Yim et al., eLife)
    2022/04/20
    Evolutionary diversification of the autophagy-related ubiquitin-like conjugation systems (Zhang et al., Autophagy)
    2022/04/20
    Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins (Chino et al., EMBO Rep.)
    2022/04/20
    Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair (Yim et al., FEBS Lett)
    2021/11/23
    An exploratory text analysis of the autophagy research field (Yim, et al., Autophagy)
    2021/06/02
    NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA (Yamamoto, et al., Nat. Commun.)
    2021/05/12
    Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy (Mimura, et al., J Biol Chem)
    2021/04/15
    Organelle degradation in the lens by PLAAT phospholipases (Morishita, et al., Nature)
    2021/04/01
    Evolution and insights into the structure and function of the DedA superfamily containing TMEM41B and VMP1 (Okawa, Hama, Zhang et al., J Cell Sci)

    Recent Publications (Review)

    and More

    2023/04/28
    Ubiquitination of non-protein substrates (Sakamaki and Mizushima, Trends Cell Biol.)
    2023/01/13
    Autophagy genes in biology and disease (Yamamoto, Zhang et al., Nat Rev Genet.)
    2022/05/25
    Transient visit of STX17 (syntaxin 17) to autophagosomes (Koyama-Honda and Mizushima, Autophagy)
    2022/02/03
    Regulation of ER-derived membrane dynamics by the DedA domain-containing proteins VMP1 and TMEM41B (Hama, Morishita et al., EMBO Rep.)
    2021/07/11
    Breakthroughs and bottlenecks in autophagy research (Mizushima, et al., Trends Mol Med)
    2021/07/01
    The evolution of autophagy proteins – diversification in eukaryotes and potential ancestors in prokaryotes (Zhang, et al., J Cell Sci)
    2020/10/15
    Autophagy in human diseases (*Mizushima, N., Levine, B. , N. Engl. J. Med, 2020)
    2020/08/22
    Beth Levine 1960-2020 (Simon et al. Nat Cell Biol. 2020)
    2020/08/21
    Autophagy assays for biological discovery and therapeutic development (Mizushima et al. Trends Biochem Sci. 2020)
    2020/03/02
    ER-phagy: Quality control and turnover of endoplasmic reticulum (Chino et al., Trends Cell Biol)
    2020/02/11
    Lysosome biology in autophagy (Yim et al., Cell Discov)
    2019/12/31
    The ATG conjugation systems in autophagy (Mizushima, Curr Opin Cell Biol)
    2019/10/06
    Diverse cellular roles of autophagy (Morishita et al., Annu Rev Cell Dev Biol)
    2019/09/15
    The ubiquitin E2 enzyme UBE2QL1 mediates lysophagy (Mizushima, EMBO Rep)
    2019/02/26
    TMEM41B functions with VMP1 in autophagosome formation (Morita et al., Autophagy)

    Go back to page TOP

    Mizushima Lab