発表論文
Selected publications
Original articles
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Yuji Sakai, Satoru Takahashi, Ikuko Koyama-Honda, Chieko Saito & Noboru Mizushima
Experimental determination and mathematical modeling of standard shapes of forming autophagosomes
Nat Commun. 2024 Jan 02
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Jun-ichi Sakamaki, Koji L. Ode, Yoshitaka Kurikawa, Hiroki R. Ueda, Hayashi Yamamoto & Noboru Mizushima
Ubiquitination of phosphatidylethanolamine in organellar membranes
Mol Cell. 2022 Aug 30
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Willa Wen-You Yim, Hayashi Yamamoto & Noboru Mizushima
A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag
eLife 2022 Aug 8
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Yasuhiro Yamamoto, Haruka Chino, Satoshi Tsukamoto, Koji L Ode, Hiroki R Ueda, Noboru Mizushima
NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA
Nat Commun 2021 Jun 2;12(1):3292.
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Hideaki Morishita, Tomoya Eguchi, Satoshi Tsukamoto, Yuriko Sakamaki, Satoru Takahashi, Chieko Saito, Ikuko Koyama-Honda, Noboru Mizushima
Organelle degradation in the lens by PLAAT phospholipases
Nature 2021 Apr;592(7855):634-638
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Morishita H, Kanda Y, Kaizuka T, Chino H, Nakao K, Miki Y, Taketomi Y, Guan J-L, Murakami M, Aiba A, Mizushima N.
Autophagy is required for maturation of surfactant-containing lamellar bodies in the lung and swim bladder
Cell Rep 2020 Dec 8; 33, 108477
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Sakai, Y., Koyama-Honda, I., Tachikawa, M., Knorr, R.L., Mizushima, N.
Modeling Membrane Morphological Change during Autophagosome Formation
iScience 2020 Aug 15;23(9):101466.
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Chino H, Hatta T, Natsume T, Mizushima N.
Intrinsically Disordered Protein TEX264 Mediates ER-phagy
Mol Cell 2019 Apr 11. pii: S1097-2765(19)30257-6.
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Pang Y, Yamamoto H, Sakamoto H, Oku M, Mutungi JK, Sahani MH, Kurikawa Y, Kita K, Noda NN, Sakai Y, Jia H, Mizushima N.
Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system
Nat Struct Mol Biol 2019 Apr;26(4):289-296
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Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, Sakamaki Y, Mimura K, Morishita H, Shihoya W, Nureki O, Mano H, Mizushima N.
Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation
J Cell Biol 2018 Nov 5;217(11):3817-3828
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Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N
Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17
J Cell Biol 2018 Aug 6;217(8):2633-2645
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Nishimura T, Tamura N, Kono N, Shimanaka Y, Arai H, Yamamoto H, Mizushima N.
Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains
EMBO J 2017 Jun 14;36(12):1719-1735
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Tsuboyama K, Koyama-Honda I, Sakamaki Y, Koike M, Morishita H, Mizushima N.
The ATG conjugation systems are important for degradation of the inner autophagosomal membrane
Science 2016 Nov 25;354(6315):1036-1041
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Kaizuka T, Morishita H, Hama Y, Tsukamoto S, Matsui T, Toyota Y, Kodama A, Ishihara T, Mizushima T, Mizushima N.
An Autophagic Flux Probe that Releases an Internal Control
Mol Cell 2016 Nov 17;64(4):835-849
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Yoshii SR, Kuma A, Akashi T, Hara T, Yamamoto A, Kurikawa Y, Itakura E, Tsukamoto S, Shitara H, Eishi Y, Mizushima N.
Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons
Dev Cell 2016 Oct 10;39(1):116-130
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Saitsu H, Nishimura T, Muramatsu K, Kodera H, Kumada S, Sugai K, Kasai-Yoshida E, Sawaura N, Nishida H, Hoshino A, Ryujin F, Yoshioka S, Nishiyama K, Kondo Y, Tsurusaki Y, Nakashima M, Miyake N, Arakawa H, Kato M, Mizushima N, Matsumoto N.
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
Nat Genet 2013 Apr;45(4):445-9, 449e1
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Itakura E, Kishi-Itakura C, Mizushima N.
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
Cell 2012 Dec 7;151(6):1256-69
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Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K, Mizushima N.
Autophagy-deficient mice develop multiple liver tumors
Genes Dev 2011 Apr 15;25(8):795-800
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Itakura E, Mizushima N.
p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3-binding
J Cell Biol 2011 Jan 10;192(1):17-27
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Nao Hosokawa, Taichi Hara, Takeshi Kaizuka, Chieko Kishi, Akito Takamura, Yutaka Miura, Shun-ichiro Iemura, Tohru Natsume, Kenji Takehana, Naoyuki Yamada, Jun-Lin Guan, Noriko Oshiro & Noboru Mizushima
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
Mol Biol Cell. 2009 Apr 20
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Eisuke Itakura, Chieko Kishi, Kinji Inoue & Noboru Mizushima
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
Mol Biol Cell. 2008 Dec 19
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Satoshi Tsukamoto, Akiko Kuma, Mirei Murakami, Chieko Kishi, Akitsugu Yamamoto & Noboru Mizushima
Autophagy is essential for preimplantation development of mouse embryos
Science. 2008 Jul 4
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Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N.
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
J Cell Biol 2008 May 5;181(3):497-510
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Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Nature 2006 Jun 15;441(7095):885-9
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Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N
The role of autophagy during the early neonatal starvation period
Nature 2004 Dec 23;432(7020):1032-6
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Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
Mol Biol Cell 2004 Mar;15(3):1101-11
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Noboru Mizushima, Akiko Kuma, Yoshinori Kobayashi, Akitsugu Yamamoto, Masami Matsubae, Toshifumi Takao, Tohru Natsume, Yoshinori Ohsumi & Tamotsu Yoshimori
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
J Cell Sci. 2003 May 1
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N Mizushima, A Yamamoto, M Hatano, Y Kobayashi, Y Kabeya, K Suzuki, T Tokuhisa, Y Ohsumi & T Yoshimori
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
J Cell Biol. 2001 Feb 19
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N Mizushima, T Noda & Y Ohsumi
Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway
EMBO J. 1999 Jul 15
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Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, George MD, Klionsky DJ, Ohsumi M, Ohsumi Y
A protein conjugation system essential for autophagy
Nature 1998 Sep 24;395(6700):395-8
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Review articles
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Jun-ichi Sakamaki & Noboru Mizushima
Ubiquitination of non-protein substrates
Trends Cell Biol. 2023 Apr 27
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Hayashi Yamamoto, Sidi Zhang & Noboru Mizushima
Autophagy genes in biology and disease
Nat Rev Genet. 2023 Jan 12
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Sidi Zhang, Yutaro Hama, Noboru Mizushima
The evolution of autophagy proteins – diversification in eukaryotes and potential ancestors in prokaryotes
J Cell Sci 2021 Jul 1;134(13):jcs233742
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Mizushima N., Murphy L. O.
Autophagy assays for biological discovery and therapeutic development
Trends Biochem Sci 2020 Aug 21;S0968-0004(20)30191-2
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*Mizushima N, Levine B
Autophagy in human diseases
N. Engl. J. Med 383:1564-1576 (2020)
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Mizushima N.
A brief history of autophagy from cell biology to physiology and disease
Nat Cell Biol 2018 May;20(5):521-527
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Mizushima N, Komatsu M
Autophagy: renovation of cells and tissues
Cell 2011 Nov 11;147(4):728-41
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Mizushima N, Yoshimori T, Levine B
Methods in mammalian autophagy research
Cell 2010 Feb 5;140(3):313-26
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Mizushima N, Levine B, Cuervo, AM, Klionsky DJ
Autophagy fights disease through cellular self-digestion
Nature 2008 Feb 28;451(7182):1069-75
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教科書など
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大隅良典監修、吉森保、水島昇、中戸川仁編集
「オートファジー 分子メカニズムの理解から病態の解明まで」(The Frontiers in Life Sciences)
南山堂 2017年
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水島昇、吉森保 編
「オートファジー―生命をささえる細胞の自己分解システム」 (DOJIN BIOSCIENCE SERIES)
化学同人 2013年
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水島昇 著
「細胞が自分を食べる オートファジーの謎」
PHPサイエンス・ワールド新書 2011年
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