発表論文

Selected publications

Original articles

Chino H, Hatta T, Natsume T, Mizushima N.
Intrinsically Disordered Protein TEX264 Mediates ER-phagy
Mol Cell 2019 Apr 11. pii: S1097-2765(19)30257-6.
Pang Y, Yamamoto H, Sakamoto H, Oku M, Mutungi JK, Sahani MH, Kurikawa Y, Kita K, Noda NN, Sakai Y, Jia H, Mizushima N.
Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system
Nat Struct Mol Biol 2019 Apr;26(4):289-296
Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, Sakamaki Y, Mimura K, Morishita H, Shihoya W, Nureki O, Mano H, Mizushima N.
Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation
J Cell Biol 2018 Nov 5;217(11):3817-3828
Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N
Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17
J Cell Biol 2018 Aug 6;217(8):2633-2645
Nishimura T, Tamura N, Kono N, Shimanaka Y, Arai H, Yamamoto H, Mizushima N.
Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains
EMBO J 2017 Jun 14;36(12):1719-1735
Tsuboyama K, Koyama-Honda I, Sakamaki Y, Koike M, Morishita H, Mizushima N.
The ATG conjugation systems are important for degradation of the inner autophagosomal membrane
Science 2016 Nov 25;354(6315):1036-1041
Kaizuka T, Morishita H, Hama Y, Tsukamoto S, Matsui T, Toyota Y, Kodama A, Ishihara T, Mizushima T, Mizushima N.
An Autophagic Flux Probe that Releases an Internal Control
Mol Cell 2016 Nov 17;64(4):835-849
Yoshii SR, Kuma A, Akashi T, Hara T, Yamamoto A, Kurikawa Y, Itakura E, Tsukamoto S, Shitara H, Eishi Y, Mizushima N.
Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons
Dev Cell 2016 Oct 10;39(1):116-130
Saitsu H, Nishimura T, Muramatsu K, Kodera H, Kumada S, Sugai K, Kasai-Yoshida E, Sawaura N, Nishida H, Hoshino A, Ryujin F, Yoshioka S, Nishiyama K, Kondo Y, Tsurusaki Y, Nakashima M, Miyake N, Arakawa H, Kato M, Mizushima N, Matsumoto N.
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
Nat Genet 2013 Apr;45(4):445-9, 449e1
Itakura E, Kishi-Itakura C, Mizushima N.
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
Cell 2012 Dec 7;151(6):1256-69
Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K, Mizushima N.
Autophagy-deficient mice develop multiple liver tumors
Genes Dev 2011 Apr 15;25(8):795-800
Itakura E, Mizushima N.
p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3-binding
J Cell Biol 2011 Jan 10;192(1):17-27
Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N.
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
J Cell Biol 2008 May 5;181(3):497-510
Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Nature 2006 Jun 15;441(7095):885-9
Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N
The role of autophagy during the early neonatal starvation period
Nature 2004 Dec 23;432(7020):1032-6
Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
Mol Biol Cell 2004 Mar;15(3):1101-11
Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, George MD, Klionsky DJ, Ohsumi M, Ohsumi Y
A protein conjugation system essential for autophagy
Nature 1998 Sep 24;395(6700):395-8

Review articles

Mizushima N.
A brief history of autophagy from cell biology to physiology and disease
Nat Cell Biol 2018 May;20(5):521-527
Mizushima N, Komatsu M
Autophagy: renovation of cells and tissues
Cell 2011 Nov 11;147(4):728-41
Mizushima N, Yoshimori T, Levine B
Methods in mammalian autophagy research
Cell 2010 Feb 5;140(3):313-26
Mizushima N, Levine B, Cuervo, AM, Klionsky DJ
Autophagy fights disease through cellular self-digestion
Nature 2008 Feb 28;451(7182):1069-75

教科書など

大隅良典監修、吉森保、水島昇、中戸川仁編集
「オートファジー 分子メカニズムの理解から病態の解明まで」(The Frontiers in Life Sciences)
南山堂 2017年
水島昇、吉森保 編
「オートファジー―生命をささえる細胞の自己分解システム」 (DOJIN BIOSCIENCE SERIES)
化学同人 2013年
水島昇 著
「細胞が自分を食べる オートファジーの謎」
PHPサイエンス・ワールド新書 2011年

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