発表論文

Original

2019年

Morishita H, Zhao Y, Tamura N, Nishimura T, Kanda Y, Sakamaki Y, Okazaki M, Li D, Mizushima N
A critical role of VMP1 in lipoprotein secretion
eLife, 2019, Sept 17 DOI: 10.7554/eLife.48834
Chino H, Hatta T, Natsume T, Mizushima N.
Intrinsically Disordered Protein TEX264 Mediates ER-phagy
Mol Cell 2019 Apr 11. pii: S1097-2765(19)30257-6.
DeVorkin L, Pavey N, Carleton G, Comber A, Ho C, Lim J, McNamara E, Huang H, Kim P, Zacharias LG, Mizushima N, Saitoh T, Akira S, Beckham W, Lorzadeh A, Moksa M, Cao Q, Murthy A, Hirst M, DeBerardinis RJ, Lum JJ
Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity
Cell Rep 2019 Apr 9;27(2):502-513.e5
Saito T, Kuma A, Sugiura Y, Ichimura Y, Obata M, Kitamura H, Okuda S, Lee HC, Ikeda K, Kanegae Y, Saito I, Auwerx J, Motohashi H, Suematsu M, Soga T, Yokomizo T, Waguri S, Mizushima N, Komatsu M
Autophagy regulates lipid metabolism through selective turnover of NCoR1
Nat Commun 2019 Apr 5;10(1):1567
Pang Y, Yamamoto H, Sakamoto H, Oku M, Mutungi JK, Sahani MH, Kurikawa Y, Kita K, Noda NN, Sakai Y, Jia H, Mizushima N.
Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system
Nat Struct Mol Biol 2019 Apr;26(4):289-296

2018年

Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, Sakamaki Y, Mimura K, Morishita H, Shihoya W, Nureki O, Mano H, Mizushima N.
Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation
J Cell Biol 2018 Nov 5;217(11):3817-3828
Takahashi S, Kagami Y, Hanaoka K, Terai T, Komatsu T, Ueno T, Uchiyama M, Koyama-Honda I, Mizushima N, Taguchi T, Arai H, Nagano T, Urano Y
Development of a series of practical fluorescent chemical tools to measure pH values in living samples
J Am Chem Soc 2018 May 9;140(18):5925-5933
Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N
Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17
J Cell Biol 2018 Aug 6;217(8):2633-2645
Wallot-Hieke N, Verma N, Schlütermann D, Berleth N, Deitersen J, Böhler P, Stuhldreier F, Wu W, Seggewiß S, Peter C, Gohlke H, Mizushima N, Stork B.
Systematic analysis of ATG13 domain requirements for autophagy induction
Autophagy 2018;14(5):743-763

2017年

Tamura N, Nishimura T, Sakamaki Y, Koyama-Honda I, Yamamoto H, Mizushima N.
Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets.
FEBS Lett 2017 Dec; 591(23):3819-3830
Uematsu M, Nishimura T, Sakamaki Y, Yamamoto H, Mizushima N.
Accumulation of undegraded autophagosomes by expression of dominant-negative STX17 (syntaxin 17) mutants.
Autophagy 2017 Aug 3;13(8):1452-1464
Fujimoto C, Iwasaki S, Urata S, Morishita H, Sakamaki Y, Fujioka M, Kondo K, Mizushima N, Yamasoba T.
Autophagy is essential for hearing in mice
Cell Death Dis 2017 May 11;8(5):e2780
Nishimura T, Tamura N, Kono N, Shimanaka Y, Arai H, Yamamoto H, Mizushima N.
Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains
EMBO J 2017 Jun 14;36(12):1719-1735
Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T.
Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy
JCI Insight 2017 Jan 12;2(1):e89462
Fujita N, Huang W, Lin TH, Groulx JF, Jean S, Nguyen J, Kuchitsu Y, Koyama-Honda I, Mizushima N, Fukuda M, Kiger AA.
Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy
Elife 2017 Jan 7;6. pii: e23367

2016年

Tsuboyama K, Koyama-Honda I, Sakamaki Y, Koike M, Morishita H, Mizushima N.
The ATG conjugation systems are important for degradation of the inner autophagosomal membrane
Science 2016 Nov 25;354(6315):1036-1041
Kaizuka T, Morishita H, Hama Y, Tsukamoto S, Matsui T, Toyota Y, Kodama A, Ishihara T, Mizushima T, Mizushima N.
An Autophagic Flux Probe that Releases an Internal Control
Mol Cell 2016 Nov 17;64(4):835-849
Yoshii SR, Kuma A, Akashi T, Hara T, Yamamoto A, Kurikawa Y, Itakura E, Tsukamoto S, Shitara H, Eishi Y, Mizushima N.
Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons
Dev Cell 2016 Oct 10;39(1):116-130
Wang C, Chen S, Yeo S, Karsli-Uzunbas G, White E, Mizushima N, Virgin HW, Guan JL.
Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide
J Cell Biol 2016 Feb 29;212(5):545-60

2015年

Kaizuka T, Mizushima N.
Atg13 Is Essential for Autophagy and Cardiac Development in Mice
Mol Cell Biol 2015 Dec 7;36(4):585-95
Hieke N, Löffler AS, Kaizuka T, Berleth N, Böhler P, Drießen S, Stuhldreier F, Friesen O, Assani K, Schmitz K, Peter C, Diedrich B, Dengjel J, Holland P, Simonsen A, Wesselborg S, Mizushima N, Stork B.q
Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells
Autophagy 2015;11(9):1471-83
Zhao YG, Sun L, Miao G, Ji C, Zhao H, Sun H, Miao L, Yoshii SR, Mizushima N, Wang X, Zhang H.
The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis
Autophagy 2015;11(6):881-90
Suzuki H, Kaizuka T, Mizushima N, Noda NN.
Structure of the Atg101-Atg13 complex reveals essential roles of Atg101 in autophagy initiation
Nat Struct Mol Biol 2015 Jul;22(7):572-80
Schlie K, Westerback A, DeVorkin L, Hughson LR, Brandon JM, MacPherson S, Gadawski I, Townsend KN, Poon VI, Elrick MA, Côté HC, Abraham N, Wherry EJ, Mizushima N, Lum JJ.
Survival of effector CD8+ T cells during influenza infection is dependent on autophagy
J Immunol 2015 May 1;194(9):4277-86

2014年

Ishihara T, Ban-Ishihara R, Maeda M, Matsunaga Y, Ichimura A, Kyogoku S, Aoki H, Katada S, Nakada K, Nomura M, Mizushima N, Mihara K, Ishihara N.
Dynamics of Mitochondrial DNA Nucleoids Regulated by Mitochondrial Fission Is Essential for Maintenance of Homogeneously Active Mitochondria during Neonatal Heart Development
Mol Cell Biol 2015 Jan;35(1):211-23
Lin HH, Lin SM, Chung Y, Vonderfecht S, Camden JM, Flodby P, Borok Z, Limesand KH, Mizushima N, Ann DK.
Dynamic involvement of ATG5 in cellular stress responses
Cell Death Dis 2014 Oct 23;5:e1478.
Udagawa O, Ishihara T, Maeda M, Matsunaga Y, Tsukamoto S, Kawano N, Miyado K, Shitara H, Yokota S, Nomura M, Mihara K, Mizushima N, Ishihara N.
Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles
Curr Biol 2014 Oct 20;24(20):2451-8
Kishi-Itakura C, Koyama-Honda I, Itakura E, Mizushima N.
Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells
J Cell Sci 2014 Sep 15;127(Pt 18):4089-102
Ogasawara Y, Itakura E, Kono N, Mizushima N, Arai H, Nara A, Mizukami T, Yamamoto A.
Stearoyl-CoA desaturase 1 activity is required for autophagosome formation
J Biol Chem 2014 Aug 22;289(34):23938-50
Yamamoto A, Mizushima N, Tsukamoto S.
Fertilization-induced autophagy in mouse embryos is independent of mTORC1
Biol Reprod 2014 Jul;91(1):7
Jiang P, Nishimura T, Sakamaki Y, Itakura E, Hatta T, Natsume T, Mizushima N.
The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17
Mol Biol Cell 2014 Apr;25(8):1327-37
Sahani MH, Itakura E, Mizushima N.
Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids
Autophagy 2014 Mar;10(3):431-41
Watanabe-Asano T, Kuma A, Mizushima N.
Cycloheximide inhibits starvation-induced autophagy through mTORC1 activation
Biochem Biophys Res Commun 2014 Mar 7;445(2):334-9

2013年

Karanasios E, Stapleton E, Manifava M, Kaizuka T, Mizushima N, Walker SA, Ktistakis NT.
Dynamic association of the ULK1 complex with omegasomes during autophagy induction
J Cell Sci 2013 Nov 15;126(Pt 22):5224-38
Koyama-Honda I, Itakura E, Fujiwara TK, Mizushima N.
Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site
Autophagy 2013 Oct;9(10):1491-9
Seino J, Wang L, Harada Y, Huang C, Ishii K, Mizushima N, Suzuki T.
Basal autophagy is required for the efficient catabolism of sialyloligosaccharides
J Biol Chem 2013 Sep 13;288(37):26898-907
Naito T, Kuma A, Mizushima N.
Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle
J Biol Chem 2013 Jul 19;288(29):21074-81
Morishita H, Eguchi S, Kimura H, Sasaki J, Sakamaki Y, Robinson ML, Sasaki T, Mizushima N.
Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation
J Biol Chem 2013 Apr 19;288(16):11436-47
Saitsu H, Nishimura T, Muramatsu K, Kodera H, Kumada S, Sugai K, Kasai-Yoshida E, Sawaura N, Nishida H, Hoshino A, Ryujin F, Yoshioka S, Nishiyama K, Kondo Y, Tsurusaki Y, Nakashima M, Miyake N, Arakawa H, Kato M, Mizushima N, Matsumoto N.
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
Nat Genet 2013 Apr;45(4):445-9, 449e1
Nishimura T, Kaizuka T, Cadwell K, Sahani MH, Saitoh T, Akira S, Virgin HW, Mizushima N.
FIP200 regulates targeting of Atg16L1 to the isolation membrane
EMBO Rep 2013 Mar 1;14(3):284-91

2012年

Itakura E, Kishi-Itakura C, Mizushima N.
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
Cell 2012 Dec 7;151(6):1256-69
Quy PN, Kuma A, Pierre P, Mizushima N.
Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation
J Biol Chem 2013 Jan 11;288(2):1125-34
Onoue K, Jofuku A, Ban-Ishihara R, Ishihara T, Maeda M, Koshiba T, Itoh T, Fukuda M, Otera H, Oka T, Takano H, Mizushima N, Mihara K, Ishihara N.
Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology
J Cell Sci 2013 Jan 1;126(Pt 1):176-85
Lin TC, Chen YR, Kensicki E, Li AY, Kong M, Li Y, Mohney RP, Shen HM, Stiles B, Mizushima N, Lin LI, Ann DK.
Autophagy: resetting glutamine-dependent metabolism and oxygen consumption
Autophagy 2012 Oct;8(10):1477-93
Imaizumi Y, Okada Y, Akamatsu W, Koike M, Kuzumaki N, Hayakawa H, Nihira T, Kobayashi T, Ohyama M, Sato S, Takanashi M, Funayama M, Hirayama A, Soga T, Hishiki T, Suematsu M, Yagi T, Ito D, Kosakai A, Hayashi K, Shouji M, Nakanishi A, Suzuki N, Mizuno Y, Mizushima N, Amagai M, Uchiyama Y, Mochizuki H, Hattori N, Okano H.
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
Mol Brain 2012 Oct 6;5:35
Kitamura K, Kishi-Itakura C, Tsuboi T, Sato S, Kita K, Ohta N, Mizushima N.
Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum
PLoS One 2012;7(8):e42977
Liu S, Hartleben B, Kretz O, Wiech T, Igarashi P, Mizushima N, Walz G, Huber TB.
Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury
Autophagy 2012 May 1;8(5):826-37
Velikkakath AK, Nishimura T, Oita E, Ishihara N, Mizushima N.
Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets
Mol Biol Cell 2012 Mar;23(5):896-909
Itakura E, Kishi-Itakura C, Koyama-Honda I, Mizushima N.
Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
J Cell Sci 2012 Mar 15;125(Pt 6):1488-99

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