メンバー紹介

  • 特任助教

    坂巻　純一

    プロフィール

    2010年　日本学術振興会　特別研究員 2011年　筑波大学大学院生命環境科学研究科 博士課程修（深水昭吉研究室） 2011年　筑波大学先端学際領域研究センター 博士研究員（深水昭吉研究室） 2011年　Children’s Hospital of Eastern Ontario Research Institute, 　　　　 Postdoctoral fellow (Robert Screaton’s Lab) 2014年　Cancer Research UK Beatson Institute, 　　　　　Postdoctoral fellow (Kevin Ryan’s Lab) 2018年　東京大学大学院医学系研究科　特任助教

    原著論文

    Bromodomain protein BRD4 is a transcriptional repressor of autophagy and lysosomal function. J. Sakamaki, S. Wilkinson, M. Hahn, N. Tasdemir, J. O’Prey, W. Clark, A. Hedley, C. Nixon, J. S. Long, M. New, T. V. Acker, S. A. Tooze, S.t W. Lowe, I. Dikic, K. M. Ryan. Mol. Cell. 2017; 66: 517-532 .
    Application of CRISPR/Cas9 to Autophagy Research. J. O'Prey, J. Sakamaki, A. D. Baudot, M. New, T. V. Acker. Methods Enzymol. 2017; 588: 79-108.
    Non-transcriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis. H. Daitoku, Y. Kaneko, K. Yoshimochi, K. Matsumoto, S. Araoi, J. Sakamaki, Y. Takahashi, A. Fukamizu. Mol. Cell. Biol. 2016; 36: 2755-2766.
    Role of the SIK2-p35-PJA2 complex in pancreatic beta cell functional compensation. J. Sakamaki, A. Fu, C. Reeks, S. Baird, C. Depatie, M. A. Azzabi, N. Bardeesy, A.-C. Gingras, S.-P. Yee, R. A. Screaton. Nat. Cell Biol. 2014; 16: 234-244 . This article was highlighted in the News and Views of Nature Cell Biology and the Editors’ choice of Science Signaling . This article was also selected by Faculty of 1000.
    GSK3β regulates gluconeogenic gene expression through HNF4α and FOXO1. J. Sakamaki, H. Daitoku, Y. Kaneko, A. Hagiwara, K. Ueno, A. Fukamizu. J. Recept. Signal Transduct. Res. 2012; 32: 96-101.
    Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt. J. Sakamaki, H. Daitoku, K. Ueno, A. Hagiwara, K. Yamagata, A. Fukamizu. Proc. Natl. Acad. Sci. USA. 2011; 108: 6085-6090. This article was featured as a Research highlight in Nature Structural and Molecular Biology .
    Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1. J. Sakamaki, H. Daitoku, K. Yoshimochi, M. Miwa, A. Fukamizu. Biochem. Biophys. Res. Commun. 2009; 382: 497-502.
    A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding. K. Hirota, J. Sakamaki, J. Ishida, Y. Shimamoto, S. Nishihara, N. Kodama, K. Ohta, M. Yamamoto, K. Tanimoto, A. Fukamizu. J. Biol. Chem. 2008; 283: 32432-32441.
    Emerging roles of transcriptional programs in autophagy regulation. J. Sakamaki, J. S. Long, M. New, T. V. Acker, S. A. Tooze, K. M. Ryan. Transcription. 2018; 9: 131-136.
    Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4. J. Sakamaki, K. M. Ryan. Autophagy. 2017; 13: 2006-2007.
    Molecular Pathways Controlling Autophagy in Pancreatic Cancer. M. New, T. V. Acker, J. S. Long, J. Sakamaki, K. M. Ryan, S. A. Tooze. Front. Oncol. 2017; 7: 1-11.
    Autophagy Determines the Path on the TRAIL to Death. J. Sakamaki, K. M. Ryan. Dev. Cell. 2016; 37: 291-293.
    Regulation of FoxO transcription factors by acetylation and protein-protein interactions. H. Daitoku, J. Sakamaki, A. Fukamizu. Biochim. Biophys. Acta. 2011; 1813: 1954-1960.
    転写因子修飾の新しい展開. 坂巻　純一, 深水　昭吉. 医学のあゆみ、2011年、237巻6号、617-622.

  • 特任助教

    栗川　義峻

    プロフィール

    2013年　東京大学医学部医学科卒業 2017年　東京大学大学院医学系研究科修了（医学博士） 2018年- 東京大学大学院医学系研究科特任研究員

    原著論文

    Saori R. Yoshii*, Akiko Kuma* (*equally contributed), Takumi Akashi, Taichi Hara, Atsushi Yamamoto, Yoshitaka Kurikawa, Eisuke Itakura, Satoshi Tsukamoto, Hiroshi Shitara, Yoshinobu Eishi, Noboru Mizushima. Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons. Dev Cell 2016 Oct 10;39(1):116-130
    Yanagida K, Kurikawa Y, Shimizu T, Ishii S. Current progress in non-Edg family LPA receptor research. Biochim Biophys Acta. 2013 Jan;1831(1):33-41. Epub 2012 Aug 11.
    Pang Y, Yamamoto H, Sakamoto H, Oku M, Mutungi JK, Sahani MH, Kurikawa Y, Kita K, Noda NN, Sakai Y, Jia H, Mizushima N. Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system. Nat Struct Mol Biol. 2019 Apr;26(4):289-296
    Tsukasaki M, Huynh NC, Okamoto K, Muro R, Terashima A, Kurikawa Y, Komatsu N, Pluemsakunthai W, Nitta T, Abe T, Kiyonari H, Okamura T, Sakai M, Matsukawa T, Matsumoto M, Kobayashi Y, Penninger JM, Takayanagi H. Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution. Nat Metab. 2020 Dec;2(12):1382-1390
    Willa Wen-You Yim, Yoshitaka Kurikawa, Noboru Mizushima An exploratory text analysis of the autophagy research field Autophagy. 2022 Jul;18(7):1648-1661. doi: 10.1080/15548627.2021.1995151. Epub 2021 Nov 23.
    Jun-ichi Sakamaki, Koji L. Ode, Yoshitaka Kurikawa, Hiroki R. Ueda, Hayashi Yamamoto & Noboru Mizushima Ubiquitination of phosphatidylethanolamine in organellar membranes Mol Cell. 2022 Aug 30
    Shunsuke Ishii, Haruka Chino, Koji L Ode, Yoshitaka Kurikawa, Hiroki R Ueda, Akira Matsuura, Noboru Mizushima, Eisuke Itakura CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy Mol Biol Cell. 2023 Apr 1;34(4):ar29. doi: 10.1091/mbc.E22-09-0432. Epub 2023 Feb 3.

    総説論文

    栗川義峻、水島昇 mTOR複合体・AMPKとオートファジー The Lipid 26(1), 40-47, 2015
    栗川義峻、水島昇 オートファジー・リソソームの活性制御と飢餓応答 細胞　(2019)
    栗川義峻 オートファジー研究におけるプロテオミクス 医学のあゆみ 272巻9号 (2020)

    ひとこと： Scienceをしたいです。 趣味： テニス

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