Publications
Original
2024
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Zi Yang, Saori R. Yoshii, Yuji Sakai, Jing Zhang, Haruka Chino, Roland L. Knorr & Noboru Mizushima
Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates
EMBO J 2024 Oct 17
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Yoshitaka Kurikawa, Ikuko Koyama-Honda, Keiko Igarashi, Norito Tamura, Seiichi Koike & Noboru Mizushima
Optogenetic tools for inducing organelle membrane rupture
bioRxiv 2024 Aug 13
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Yoshitaka Kurikawa, Ikuko Koyama-Honda, Keiko Igarashi, Norito Tamura, Seiichi Koike & Noboru Mizushima
Organelle landscape analysis using a multi-parametric particle-based method
PLoS Biol. 2024 Sep 17
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Saori Shinoda, Yuji Sakai, Takahide Matsui, Masaaki Uematsu, Ikuko Koyama-Honda, Jun-ichi Sakamaki, Hayashi Yamamoto & Noboru Mizushima
Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation
eLife 2024 Jun 4
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Yuji Sakai, Satoru Takahashi, Ikuko Koyama-Honda, Chieko Saito & Noboru Mizushima
Experimental determination and mathematical modeling of standard shapes of forming autophagosomes
Nat Commun. 2024 Jan 02
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2023
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Yutaro Hama, Yoshitaka Kurikawa, Takahide Matsui, Noboru Mizushima & Hayashi Yamamoto
TAX1BP1 recruits ATG9 vesicles through SCAMP3 binding
bioRxiv 2023 Aug 18
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Takahiro Shimizu, Norito Tamura, Taki Nishimura, Chieko Saito, Hayashi Yamamoto & Noboru Mizushima
Comprehensive analysis of autophagic functions of WIPI family proteins and their implications for the pathogenesis of β-propeller associated neurodegeneration
Hum Mol Genet. 2023 Jun 26
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Taki Nishimura, Gianmarco Lazzeri, Noboru Mizushima, Roberto Covino & Sharon A Tooze
Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3
Sci Adv . 2023 Jun 23
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Masaru Shimasawa, Jun-Ichi Sakamaki, Maeda Tatsuya & Noboru Mizushima
The pH-sensing Rim101 pathway regulates cell size in budding yeast
J Biol Chem. 2023 Feb 2
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2022
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Satoru Takahashi, Chieko Saito, Ikuko Koyama-Honda & Noboru Mizushima
Quantitative 3D correlative light and electron microscopy of organelle association during autophagy
Cell Struct Funct. 2022 Dec 22
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Tomoko Ohshima, Hayashi Yamamoto, Yuriko Sakamaki, Chieko Saito & Noboru Mizushima
NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy
J. Cell Biol. 2022 Sep 6
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Jun-ichi Sakamaki, Koji L. Ode, Yoshitaka Kurikawa, Hiroki R. Ueda, Hayashi Yamamoto & Noboru Mizushima
Ubiquitination of phosphatidylethanolamine in organellar membranes
Mol Cell. 2022 Aug 30
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Willa Wen-You Yim, Hayashi Yamamoto & Noboru Mizushima
A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag
eLife 2022 Aug 8
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Sidi Zhang, Euki Yazaki, Hirokazu Sakamoto, Hayashi Yamamoto, Noboru Mizushima
Evolutionary diversification of the autophagy-related ubiquitin-like conjugation systems
Autophagy 2022 Apr 15
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Haruka Chino, Akinori Yamasaki, Koji L Ode, Hiroki R Ueda, Nobuo N Noda, Noboru Mizushima
Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins
EMBO Rep . 2022 Apr 13
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Willa Wen-You Yim,Hayashi Yamamoto,Noboru Mizushima
Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair
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2021
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Willa Wen-You Yim, Yoshitaka Kurikawa, Noboru Mizushima
An exploratory text analysis of the autophagy research field
Autophagy 2021 Nov 23;1-14
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Yasuhiro Yamamoto, Haruka Chino, Satoshi Tsukamoto, Koji L Ode, Hiroki R Ueda, Noboru Mizushima
NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA
Nat Commun 2021 Jun 2;12(1):3292.
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Kaito Mimura, Jun-ichi Sakamaki, Hideaki Morishita, Masahito Kawazu, Hiroyuki Mano, Noboru Mizushima
Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy
J Biol Chem S0021-9258(21)00573-1
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Fumiya Okawa*, Yutaro Hama*, Sidi Zhang*, Hideaki Morishita, Hayashi Yamamoto, Tim P. Levine, Noboru Mizushima (* equally contributed)
Evolution and insights into the structure and function of the DedA superfamily containing TMEM41B and VMP1
J Cell Sci . 2021 Apr 15;134(8):jcs255877
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Hideaki Morishita, Tomoya Eguchi, Satoshi Tsukamoto, Yuriko Sakamaki, Satoru Takahashi, Chieko Saito, Ikuko Koyama-Honda, Noboru Mizushima
Organelle degradation in the lens by PLAAT phospholipases
Nature 2021 Apr;592(7855):634-638
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Jaime Agudo-Canalejo, Sebastian W Schultz, Haruka Chino, Simona M Migliano, Chieko Saito, Ikuko Koyama-Honda, Harald Stenmark, Andreas Brech, Alexander I May, Noboru Mizushima, Roland L Knorr
Wetting regulates autophagy of phase-separated compartments and the cytosol
Nature 2021 Mar;591(7848):142-146
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2020
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Shintaro Maeda, Hayashi Yamamoto, Lisa N Kinch, Christina M Garza, Satoru Takahashi, Chinatsu Otomo, Nick V Grishin, Stefano Forli, Noboru Mizushima, Takanori Otomo
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A
Nat Struct Mol Biol 2020 Dec;27(12):1194-1201
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Morishita H, Kanda Y, Kaizuka T, Chino H, Nakao K, Miki Y, Taketomi Y, Guan J-L, Murakami M, Aiba A, Mizushima N.
Autophagy is required for maturation of surfactant-containing lamellar bodies in the lung and swim bladder
Cell Rep 2020 Dec 8; 33, 108477
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Sakai, Y., Koyama-Honda, I., Tachikawa, M., Knorr, R.L., Mizushima, N.
Modeling Membrane Morphological Change during Autophagosome Formation
iScience 2020 Aug 15;23(9):101466.
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2019
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Takahashi, S.S., Sou, Y.S., Saito, T., Kuma, A., Yabe, T., Sugiura, Y., Lee, H.C., Suematsu, M., Yokomizo, T., Koike, M., Terai, S., Mizushima, N., Waguri, S., Komatsu, M
Loss of autophagy impairs physiological steatosis by accumulation of NCoR12
Life Sci. Alliance, 3. pii: e201900513 (2019)
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Morishita H, Zhao Y, Tamura N, Nishimura T, Kanda Y, Sakamaki Y, Okazaki M, Li D, Mizushima N
A critical role of VMP1 in lipoprotein secretion
eLife, 2019, Sept 17 DOI: 10.7554/eLife.48834
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Chino H, Hatta T, Natsume T, Mizushima N.
Intrinsically Disordered Protein TEX264 Mediates ER-phagy
Mol Cell 2019 Apr 11. pii: S1097-2765(19)30257-6.
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DeVorkin L, Pavey N, Carleton G, Comber A, Ho C, Lim J, McNamara E, Huang H, Kim P, Zacharias LG, Mizushima N, Saitoh T, Akira S, Beckham W, Lorzadeh A, Moksa M, Cao Q, Murthy A, Hirst M, DeBerardinis RJ, Lum JJ
Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity
Cell Rep 2019 Apr 9;27(2):502-513.e5
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Saito T, Kuma A, Sugiura Y, Ichimura Y, Obata M, Kitamura H, Okuda S, Lee HC, Ikeda K, Kanegae Y, Saito I, Auwerx J, Motohashi H, Suematsu M, Soga T, Yokomizo T, Waguri S, Mizushima N, Komatsu M
Autophagy regulates lipid metabolism through selective turnover of NCoR1
Nat Commun 2019 Apr 5;10(1):1567
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Pang Y, Yamamoto H, Sakamoto H, Oku M, Mutungi JK, Sahani MH, Kurikawa Y, Kita K, Noda NN, Sakai Y, Jia H, Mizushima N.
Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system
Nat Struct Mol Biol 2019 Apr;26(4):289-296
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2018
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Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, Sakamaki Y, Mimura K, Morishita H, Shihoya W, Nureki O, Mano H, Mizushima N.
Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation
J Cell Biol 2018 Nov 5;217(11):3817-3828
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Takahashi S, Kagami Y, Hanaoka K, Terai T, Komatsu T, Ueno T, Uchiyama M, Koyama-Honda I, Mizushima N, Taguchi T, Arai H, Nagano T, Urano Y
Development of a series of practical fluorescent chemical tools to measure pH values in living samples
J Am Chem Soc 2018 May 9;140(18):5925-5933
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Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N
Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17
J Cell Biol 2018 Aug 6;217(8):2633-2645
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Wallot-Hieke N, Verma N, Schlütermann D, Berleth N, Deitersen J, Böhler P, Stuhldreier F, Wu W, Seggewiß S, Peter C, Gohlke H, Mizushima N, Stork B.
Systematic analysis of ATG13 domain requirements for autophagy induction
Autophagy 2018;14(5):743-763
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2017
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Tamura N, Nishimura T, Sakamaki Y, Koyama-Honda I, Yamamoto H, Mizushima N.
Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets.
FEBS Lett 2017 Dec; 591(23):3819-3830
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Uematsu M, Nishimura T, Sakamaki Y, Yamamoto H, Mizushima N.
Accumulation of undegraded autophagosomes by expression of dominant-negative STX17 (syntaxin 17) mutants.
Autophagy 2017 Aug 3;13(8):1452-1464
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Fujimoto C, Iwasaki S, Urata S, Morishita H, Sakamaki Y, Fujioka M, Kondo K, Mizushima N, Yamasoba T.
Autophagy is essential for hearing in mice
Cell Death Dis 2017 May 11;8(5):e2780
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Nishimura T, Tamura N, Kono N, Shimanaka Y, Arai H, Yamamoto H, Mizushima N.
Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains
EMBO J 2017 Jun 14;36(12):1719-1735
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Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T.
Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy
JCI Insight 2017 Jan 12;2(1):e89462
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Fujita N, Huang W, Lin TH, Groulx JF, Jean S, Nguyen J, Kuchitsu Y, Koyama-Honda I, Mizushima N, Fukuda M, Kiger AA.
Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy
Elife 2017 Jan 7;6. pii: e23367
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2016
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Tsuboyama K, Koyama-Honda I, Sakamaki Y, Koike M, Morishita H, Mizushima N.
The ATG conjugation systems are important for degradation of the inner autophagosomal membrane
Science 2016 Nov 25;354(6315):1036-1041
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Kaizuka T, Morishita H, Hama Y, Tsukamoto S, Matsui T, Toyota Y, Kodama A, Ishihara T, Mizushima T, Mizushima N.
An Autophagic Flux Probe that Releases an Internal Control
Mol Cell 2016 Nov 17;64(4):835-849
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Yoshii SR, Kuma A, Akashi T, Hara T, Yamamoto A, Kurikawa Y, Itakura E, Tsukamoto S, Shitara H, Eishi Y, Mizushima N.
Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons
Dev Cell 2016 Oct 10;39(1):116-130
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Wang C, Chen S, Yeo S, Karsli-Uzunbas G, White E, Mizushima N, Virgin HW, Guan JL.
Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide
J Cell Biol 2016 Feb 29;212(5):545-60
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2015
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Kaizuka T, Mizushima N.
Atg13 Is Essential for Autophagy and Cardiac Development in Mice
Mol Cell Biol 2015 Dec 7;36(4):585-95
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Hieke N, Löffler AS, Kaizuka T, Berleth N, Böhler P, Drießen S, Stuhldreier F, Friesen O, Assani K, Schmitz K, Peter C, Diedrich B, Dengjel J, Holland P, Simonsen A, Wesselborg S, Mizushima N, Stork B.q
Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells
Autophagy 2015;11(9):1471-83
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Zhao YG, Sun L, Miao G, Ji C, Zhao H, Sun H, Miao L, Yoshii SR, Mizushima N, Wang X, Zhang H.
The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis
Autophagy 2015;11(6):881-90
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Suzuki H, Kaizuka T, Mizushima N, Noda NN.
Structure of the Atg101-Atg13 complex reveals essential roles of Atg101 in autophagy initiation
Nat Struct Mol Biol 2015 Jul;22(7):572-80
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Schlie K, Westerback A, DeVorkin L, Hughson LR, Brandon JM, MacPherson S, Gadawski I, Townsend KN, Poon VI, Elrick MA, Côté HC, Abraham N, Wherry EJ, Mizushima N, Lum JJ.
Survival of effector CD8+ T cells during influenza infection is dependent on autophagy
J Immunol 2015 May 1;194(9):4277-86
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2014
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Ishihara T, Ban-Ishihara R, Maeda M, Matsunaga Y, Ichimura A, Kyogoku S, Aoki H, Katada S, Nakada K, Nomura M, Mizushima N, Mihara K, Ishihara N.
Dynamics of Mitochondrial DNA Nucleoids Regulated by Mitochondrial Fission Is Essential for Maintenance of Homogeneously Active Mitochondria during Neonatal Heart Development
Mol Cell Biol 2015 Jan;35(1):211-23
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Lin HH, Lin SM, Chung Y, Vonderfecht S, Camden JM, Flodby P, Borok Z, Limesand KH, Mizushima N, Ann DK.
Dynamic involvement of ATG5 in cellular stress responses
Cell Death Dis 2014 Oct 23;5:e1478.
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Udagawa O, Ishihara T, Maeda M, Matsunaga Y, Tsukamoto S, Kawano N, Miyado K, Shitara H, Yokota S, Nomura M, Mihara K, Mizushima N, Ishihara N.
Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles
Curr Biol 2014 Oct 20;24(20):2451-8
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Kishi-Itakura C, Koyama-Honda I, Itakura E, Mizushima N.
Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells
J Cell Sci 2014 Sep 15;127(Pt 18):4089-102
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Ogasawara Y, Itakura E, Kono N, Mizushima N, Arai H, Nara A, Mizukami T, Yamamoto A.
Stearoyl-CoA desaturase 1 activity is required for autophagosome formation
J Biol Chem 2014 Aug 22;289(34):23938-50
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Yamamoto A, Mizushima N, Tsukamoto S.
Fertilization-induced autophagy in mouse embryos is independent of mTORC1
Biol Reprod 2014 Jul;91(1):7
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Jiang P, Nishimura T, Sakamaki Y, Itakura E, Hatta T, Natsume T, Mizushima N.
The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17
Mol Biol Cell 2014 Apr;25(8):1327-37
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Sahani MH, Itakura E, Mizushima N.
Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids
Autophagy 2014 Mar;10(3):431-41
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Watanabe-Asano T, Kuma A, Mizushima N.
Cycloheximide inhibits starvation-induced autophagy through mTORC1 activation
Biochem Biophys Res Commun 2014 Mar 7;445(2):334-9
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2013
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Karanasios E, Stapleton E, Manifava M, Kaizuka T, Mizushima N, Walker SA, Ktistakis NT.
Dynamic association of the ULK1 complex with omegasomes during autophagy induction
J Cell Sci 2013 Nov 15;126(Pt 22):5224-38
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Koyama-Honda I, Itakura E, Fujiwara TK, Mizushima N.
Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site
Autophagy 2013 Oct;9(10):1491-9
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Seino J, Wang L, Harada Y, Huang C, Ishii K, Mizushima N, Suzuki T.
Basal autophagy is required for the efficient catabolism of sialyloligosaccharides
J Biol Chem 2013 Sep 13;288(37):26898-907
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Naito T, Kuma A, Mizushima N.
Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle
J Biol Chem 2013 Jul 19;288(29):21074-81
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Morishita H, Eguchi S, Kimura H, Sasaki J, Sakamaki Y, Robinson ML, Sasaki T, Mizushima N.
Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation
J Biol Chem 2013 Apr 19;288(16):11436-47
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Saitsu H, Nishimura T, Muramatsu K, Kodera H, Kumada S, Sugai K, Kasai-Yoshida E, Sawaura N, Nishida H, Hoshino A, Ryujin F, Yoshioka S, Nishiyama K, Kondo Y, Tsurusaki Y, Nakashima M, Miyake N, Arakawa H, Kato M, Mizushima N, Matsumoto N.
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
Nat Genet 2013 Apr;45(4):445-9, 449e1
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Nishimura T, Kaizuka T, Cadwell K, Sahani MH, Saitoh T, Akira S, Virgin HW, Mizushima N.
FIP200 regulates targeting of Atg16L1 to the isolation membrane
EMBO Rep 2013 Mar 1;14(3):284-91
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2012
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Itakura E, Kishi-Itakura C, Mizushima N.
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
Cell 2012 Dec 7;151(6):1256-69
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Quy PN, Kuma A, Pierre P, Mizushima N.
Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation
J Biol Chem 2013 Jan 11;288(2):1125-34
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Onoue K, Jofuku A, Ban-Ishihara R, Ishihara T, Maeda M, Koshiba T, Itoh T, Fukuda M, Otera H, Oka T, Takano H, Mizushima N, Mihara K, Ishihara N.
Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology
J Cell Sci 2013 Jan 1;126(Pt 1):176-85
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Lin TC, Chen YR, Kensicki E, Li AY, Kong M, Li Y, Mohney RP, Shen HM, Stiles B, Mizushima N, Lin LI, Ann DK.
Autophagy: resetting glutamine-dependent metabolism and oxygen consumption
Autophagy 2012 Oct;8(10):1477-93
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Imaizumi Y, Okada Y, Akamatsu W, Koike M, Kuzumaki N, Hayakawa H, Nihira T, Kobayashi T, Ohyama M, Sato S, Takanashi M, Funayama M, Hirayama A, Soga T, Hishiki T, Suematsu M, Yagi T, Ito D, Kosakai A, Hayashi K, Shouji M, Nakanishi A, Suzuki N, Mizuno Y, Mizushima N, Amagai M, Uchiyama Y, Mochizuki H, Hattori N, Okano H.
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
Mol Brain 2012 Oct 6;5:35
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Kitamura K, Kishi-Itakura C, Tsuboi T, Sato S, Kita K, Ohta N, Mizushima N.
Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum
PLoS One 2012;7(8):e42977
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Liu S, Hartleben B, Kretz O, Wiech T, Igarashi P, Mizushima N, Walz G, Huber TB.
Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury
Autophagy 2012 May 1;8(5):826-37
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Velikkakath AK, Nishimura T, Oita E, Ishihara N, Mizushima N.
Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets
Mol Biol Cell 2012 Mar;23(5):896-909
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Itakura E, Kishi-Itakura C, Koyama-Honda I, Mizushima N.
Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
J Cell Sci 2012 Mar 15;125(Pt 6):1488-99
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