Project Assistant Professor

  • Project Assistant Professor

    Junichi Sakamaki


    2010年 日本学術振興会 特別研究員
    2011年 筑波大学大学院生命環境科学研究科 博士課程修(深水昭吉研究室)
    2011年 筑波大学先端学際領域研究センター 博士研究員(深水昭吉研究室)
    2011年 Children’s Hospital of Eastern Ontario Research Institute,
         Postdoctoral fellow (Robert Screaton’s Lab)
    2014年 Cancer Research UK Beatson Institute,
         Postdoctoral fellow (Kevin Ryan’s Lab)
    2018年 東京大学大学院医学系研究科 特任助教

    Original Papers

    Bromodomain protein BRD4 is a transcriptional repressor of autophagy and lysosomal function. J. Sakamaki, S. Wilkinson, M. Hahn, N. Tasdemir, J. O’Prey, W. Clark, A. Hedley, C. Nixon, J. S. Long, M. New, T. V. Acker, S. A. Tooze, S.t W. Lowe, I. Dikic, K. M. Ryan. Mol. Cell. 2017; 66: 517-532 .
    Application of CRISPR/Cas9 to Autophagy Research. J. O'Prey, J. Sakamaki, A. D. Baudot, M. New, T. V. Acker. Methods Enzymol. 2017; 588: 79-108.
    Non-transcriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis. H. Daitoku, Y. Kaneko, K. Yoshimochi, K. Matsumoto, S. Araoi, J. Sakamaki, Y. Takahashi, A. Fukamizu. Mol. Cell. Biol. 2016; 36: 2755-2766.
    Role of the SIK2-p35-PJA2 complex in pancreatic beta cell functional compensation. J. Sakamaki, A. Fu, C. Reeks, S. Baird, C. Depatie, M. A. Azzabi, N. Bardeesy, A.-C. Gingras, S.-P. Yee, R. A. Screaton. Nat. Cell Biol. 2014; 16: 234-244 . This article was highlighted in the News and Views of Nature Cell Biology and the Editors’ choice of Science Signaling . This article was also selected by Faculty of 1000.
    GSK3β regulates gluconeogenic gene expression through HNF4α and FOXO1. J. Sakamaki, H. Daitoku, Y. Kaneko, A. Hagiwara, K. Ueno, A. Fukamizu. J. Recept. Signal Transduct. Res. 2012; 32: 96-101.
    Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt. J. Sakamaki, H. Daitoku, K. Ueno, A. Hagiwara, K. Yamagata, A. Fukamizu. Proc. Natl. Acad. Sci. USA. 2011; 108: 6085-6090. This article was featured as a Research highlight in Nature Structural and Molecular Biology .
    Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1. J. Sakamaki, H. Daitoku, K. Yoshimochi, M. Miwa, A. Fukamizu. Biochem. Biophys. Res. Commun. 2009; 382: 497-502.
    A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding. K. Hirota, J. Sakamaki, J. Ishida, Y. Shimamoto, S. Nishihara, N. Kodama, K. Ohta, M. Yamamoto, K. Tanimoto, A. Fukamizu. J. Biol. Chem. 2008; 283: 32432-32441.
    Emerging roles of transcriptional programs in autophagy regulation. J. Sakamaki, J. S. Long, M. New, T. V. Acker, S. A. Tooze, K. M. Ryan. Transcription. 2018; 9: 131-136.
    Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4. J. Sakamaki, K. M. Ryan. Autophagy. 2017; 13: 2006-2007.
    Molecular Pathways Controlling Autophagy in Pancreatic Cancer. M. New, T. V. Acker, J. S. Long, J. Sakamaki, K. M. Ryan, S. A. Tooze. Front. Oncol. 2017; 7: 1-11.
    Autophagy Determines the Path on the TRAIL to Death. J. Sakamaki, K. M. Ryan. Dev. Cell. 2016; 37: 291-293.
    Regulation of FoxO transcription factors by acetylation and protein-protein interactions. H. Daitoku, J. Sakamaki, A. Fukamizu. Biochim. Biophys. Acta. 2011; 1813: 1954-1960.
    転写因子修飾の新しい展開. 坂巻 純一, 深水 昭吉. 医学のあゆみ、2011年、237巻6号、617-622.

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